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Structure paper

TitleTerazosin activates Pgk1 and Hsp90 to promote stress resistance.
Journal, issue, pagesNat. Chem. Biol., Vol. 11, Page 19-25, Year 2015
Publish dateDec 18, 2013 (structure data deposition date)
AuthorsChen, X. / Zhao, C. / Li, X. / Wang, T. / Li, Y. / Cao, C. / Ding, Y. / Dong, M. / Finci, L. / Wang, J.H. / Liu, L.
External linksNat. Chem. Biol. / PubMed:25383758
MethodsX-ray diffraction
Resolution2.1 - 2.5 Å
Structure data

PDB-4o33:
Crystal Structure of human PGK1 3PG and terazosin(TZN) ternary complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4o3f:
Crystal Structure of mouse PGK1 3PG and terazosin(TZN) ternary complex
Method: X-RAY DIFFRACTION / Resolution: 2.106 Å

PDB-9ker:
Crystal structure analysis of phosphoglycerate kinase 1
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-TZN:
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl][(2R)-tetrahydrofuran-2-yl]methanone / medication*YM

ChemComp-3PG:
3-PHOSPHOGLYCERIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsTRANSFERASE/TRANSFERASE ACTIVATOR / ENZYME-DRUG COMPLEX / TRANSFERASE-TRANSFERASE ACTIVITOR complex / TRANSFERASE-TRANSFERASE ACTIVATOR complex / ONCOPROTEIN / metabolism / warburg effect.

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