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-Structure paper
Title | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. |
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Journal, issue, pages | Nat Commun, Vol. 6, Page 8250-8250, Year 2015 |
Publish date | Dec 14, 2012 (structure data deposition date) |
![]() | Deprez-Poulain, R. / Hennuyer, N. / Bosc, D. / Liang, W.G. / Enee, E. / Marechal, X. / Charton, J. / Totobenazara, J. / Berte, G. / Jahklal, J. ...Deprez-Poulain, R. / Hennuyer, N. / Bosc, D. / Liang, W.G. / Enee, E. / Marechal, X. / Charton, J. / Totobenazara, J. / Berte, G. / Jahklal, J. / Verdelet, T. / Dumont, J. / Dassonneville, S. / Woitrain, E. / Gauriot, M. / Paquet, C. / Duplan, I. / Hermant, P. / Cantrelle, F.X. / Sevin, E. / Culot, M. / Landry, V. / Herledan, A. / Piveteau, C. / Lippens, G. / Leroux, F. / Tang, W.J. / van Endert, P. / Staels, B. / Deprez, B. |
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Methods | X-ray diffraction |
Resolution | 2.73 - 3.286 Å |
Structure data | ![]() PDB-4ifh: ![]() PDB-4nxo: ![]() PDB-4re9: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-1EF: ![]() ChemComp-HOH: ![]() ChemComp-2H7: ![]() ChemComp-1PE: ![]() ChemComp-PEG: ![]() ChemComp-EDO: ![]() ChemComp-EPE: ![]() ChemComp-DIO: ![]() ChemComp-3M9: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / insulin degrading enzyme / HYDROLASE-HYDROLASE INHIBITOR complex / Hydrolase / Inhibitor / Cysteine free |