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TitleCyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Journal, issue, pagesAcs Chem. Biol., Vol. 9, Page 1128-1137, Year 2014
Publish dateDec 5, 2013 (structure data deposition date)
AuthorsMoller, S. / Alfieri, A. / Bertinetti, D. / Aquila, M. / Schwede, F. / Lolicato, M. / Rehmann, H. / Moroni, A. / Herberg, F.W.
External linksAcs Chem. Biol. / PubMed:24605759
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-4nvp:
Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-7CH:
(2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / cyclic nucleotide binding domain / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel / cytoplasmic domain

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