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Structure paper

TitleX-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 156, Page 717-729, Year 2014
Publish dateDec 2, 2013 (structure data deposition date)
AuthorsBaconguis, I. / Bohlen, C.J. / Goehring, A. / Julius, D. / Gouaux, E.
External linksCell(Cambridge,Mass. ) / PubMed:24507937
MethodsX-ray diffraction
Resolution2.07 - 2.65 Å
Structure data

PDB-4ntw:
Structure of acid-sensing ion channel in complex with snake toxin
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

PDB-4ntx:
Structure of acid-sensing ion channel in complex with snake toxin and amiloride
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

PDB-4nty:
Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-AMR:
3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE / medication*YM

ChemComp-CS:
Unknown entry

ChemComp-PE4:
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL / precipitant*YM

Source
  • gallus gallus (chicken)
  • micrurus tener tener (cobra)
KeywordsTRANSPORT PROTEIN/TOXIN / Kunitz / phospholipase A2-like / ion channel / nociception / membrane / TRANSPORT PROTEIN-TOXIN complex

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