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-Structure paper
Title | Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 24, Page 199-203, Year 2014 |
Publish date | Nov 8, 2013 (structure data deposition date) |
Authors | Deng, Y. / Shipps, G.W. / Zhao, L. / Siddiqui, M.A. / Popovici-Muller, J. / Curran, P.J. / Duca, J.S. / Hruza, A.W. / Fischmann, T.O. / Madison, V.S. ...Deng, Y. / Shipps, G.W. / Zhao, L. / Siddiqui, M.A. / Popovici-Muller, J. / Curran, P.J. / Duca, J.S. / Hruza, A.W. / Fischmann, T.O. / Madison, V.S. / Zhang, R. / McNemar, C.W. / Mayhood, T.W. / Syto, R. / Annis, A. / Kirschmeier, P. / Lees, E.M. / Parry, D.A. / Windsor, W.T. |
External links | Bioorg. Med. Chem. Lett. / PubMed:24332088 |
Methods | X-ray diffraction |
Resolution | 1.848 Å |
Structure data | PDB-4nj3: |
Chemicals | ChemComp-2KD: ChemComp-HOH: |
Source |
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Keywords | transferase/transferase inhibitor / CELL CYCLE / INHIBITION / CYCLIN-DEPENDENT KINASE / CANCER / ATP-BINDING / CELL DIVISION / MITOSIS / NUCLEOTIDE-BINDING / PHOSPHORYLATION / TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / transferase-transferase inhibitor complex |