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-Structure paper
Title | Protective hinge in insulin opens to enable its receptor engagement. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 111, Page E3395-E3404, Year 2014 |
Publish date | Feb 27, 2014 (structure data deposition date) |
![]() | Menting, J.G. / Yang, Y. / Chan, S.J. / Phillips, N.B. / Smith, B.J. / Whittaker, J. / Wickramasinghe, N.P. / Whittaker, L.J. / Pandyarajan, V. / Wan, Z.L. ...Menting, J.G. / Yang, Y. / Chan, S.J. / Phillips, N.B. / Smith, B.J. / Whittaker, J. / Wickramasinghe, N.P. / Whittaker, L.J. / Pandyarajan, V. / Wan, Z.L. / Yadav, S.P. / Carroll, J.M. / Strokes, N. / Roberts, C.T. / Ismail-Beigi, F. / Milewski, W. / Steiner, D.F. / Chauhan, V.S. / Ward, C.W. / Weiss, M.A. / Lawrence, M.C. |
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Methods | NMR (solution) / X-ray diffraction |
Resolution | 1.4 - 3.5 Å |
Structure data | ![]() PDB-2mli: ![]() PDB-2mpi: ![]() PDB-4nib: ![]() PDB-4oga: |
Chemicals | ![]() ChemComp-HOH: ![]() ChemComp-NAG: |
Source |
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![]() | HORMONE / insulin analog / PROTEIN BINDING / insulin structure / insulin mutant / HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM / CELL SURFACE RECEPTOR/IMMUNE SYSTEM / INSULIN RECEPTOR / CT PEPTIDE / INSULIN / HORMONE RECEPTOR-HORMONE-IMMUNE SYSTEM complex |