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-Structure paper
Title | Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 24, Page 917-922, Year 2014 |
Publish date | Oct 24, 2013 (structure data deposition date) |
![]() | Cote, B. / Burch, J.D. / Asante-Appiah, E. / Bayly, C. / Bedard, L. / Blouin, M. / Campeau, L.C. / Cauchon, E. / Chan, M. / Chefson, A. ...Cote, B. / Burch, J.D. / Asante-Appiah, E. / Bayly, C. / Bedard, L. / Blouin, M. / Campeau, L.C. / Cauchon, E. / Chan, M. / Chefson, A. / Coulombe, N. / Cromlish, W. / Debnath, S. / Deschenes, D. / Dupont-Gaudet, K. / Falgueyret, J.P. / Forget, R. / Gagne, S. / Gauvreau, D. / Girardin, M. / Guiral, S. / Langlois, E. / Li, C.S. / Nguyen, N. / Papp, R. / Plamondon, S. / Roy, A. / Roy, S. / Seliniotakis, R. / St-Onge, M. / Ouellet, S. / Tawa, P. / Truchon, J.F. / Vacca, J. / Wrona, M. / Yan, Y. / Ducharme, Y. |
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Methods | X-ray diffraction |
Resolution | 2.58 Å |
Structure data | ![]() PDB-4ncg: |
Chemicals | ![]() ChemComp-2KW: ![]() ChemComp-HOH: |
Source |
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![]() | Transferase/Inhhibitor / Hydrolase/Inhhibitor / HIV-1 reverse transcriptase / non-nucleoside inhibition / Wild type RT Transferase-inhibitor complex / Hydrolase-inhibitor complex / Transferase-Inhhibitor / Hydrolase-Inhhibitor complex |