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TitleThe identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 24, Page 177-180, Year 2014
Publish dateOct 15, 2013 (structure data deposition date)
AuthorsSchrder, T.J. / Christensen, S. / Lindberg, S. / Langgard, M. / David, L. / Maltas, P.J. / Eskildsen, J. / Jacobsen, J. / Tagmose, L. / Simonsen, K.B. ...Schrder, T.J. / Christensen, S. / Lindberg, S. / Langgard, M. / David, L. / Maltas, P.J. / Eskildsen, J. / Jacobsen, J. / Tagmose, L. / Simonsen, K.B. / Biilmann Rnn, L.C. / de Jong, I.E. / Malik, I.J. / Karlsson, J.J. / Bundgaard, C. / Egebjerg, J. / Stavenhagen, J.B. / Strandbygard, D. / Thirup, S. / Andersen, J.L. / Uppalanchi, S. / Pervaram, S. / Kasturi, S.P. / Eradi, P. / Sakumudi, D.R. / Watson, S.P.
External linksBioorg. Med. Chem. Lett. / PubMed:24355129
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-4n7e:
Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF38469
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-2JQ:
2-[(6-methylpyridin-2-yl)carbamoyl]-5-(trifluoromethyl)benzoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Sortilin / Small molecule ligand / AF38469 / AF40431 / proNGF / Alzheimer's disease / Beta-propeller Asp-box repeat / Vps10p domain / 10CC domain / Receptor Sorting / Membrane

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