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Title | Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 4, Page 1193-1197, Year 2013 |
Publish date | Oct 14, 2013 (structure data deposition date) |
![]() | Burger, M.T. / Han, W. / Lan, J. / Nishiguchi, G. / Bellamacina, C. / Lindval, M. / Atallah, G. / Ding, Y. / Mathur, M. / McBride, C. ...Burger, M.T. / Han, W. / Lan, J. / Nishiguchi, G. / Bellamacina, C. / Lindval, M. / Atallah, G. / Ding, Y. / Mathur, M. / McBride, C. / Beans, E.L. / Muller, K. / Tamez, V. / Zhang, Y. / Huh, K. / Feucht, P. / Zavorotinskaya, T. / Dai, Y. / Holash, J. / Castillo, J. / Langowski, J. / Wang, Y. / Chen, M.Y. / Garcia, P.D. |
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Methods | X-ray diffraction |
Resolution | 2.1 - 2.6 Å |
Structure data | ![]() PDB-4n6y: ![]() PDB-4n6z: ![]() PDB-4n70: |
Chemicals | ![]() ChemComp-2HV: ![]() ChemComp-HOH: ![]() ChemComp-2HW: ![]() ChemComp-GOL: ![]() ChemComp-2HX: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / phosphorylation / TRANSFERASE-TRANSFERASE INHIBITOR complex |