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TitleSynergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Journal, issue, pagesNature, Vol. 514, Page 646-649, Year 2014
Publish dateOct 3, 2013 (structure data deposition date)
AuthorsSackton, K.L. / Dimova, N. / Zeng, X. / Tian, W. / Zhang, M. / Sackton, T.B. / Meaders, J. / Pfaff, K.L. / Sigoillot, F. / Yu, H. ...Sackton, K.L. / Dimova, N. / Zeng, X. / Tian, W. / Zhang, M. / Sackton, T.B. / Meaders, J. / Pfaff, K.L. / Sigoillot, F. / Yu, H. / Luo, X. / King, R.W.
External linksNature / PubMed:25156254
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-4n14:
Crystal structure of Cdc20 and apcin complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-WR7:
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl [(1R)-2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE/CELL CYCLE INHIBITOR / cell cycle / mitosis / securin / ubiquitination / WD40 / CELL CYCLE-CELL CYCLE INHIBITOR complex

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