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| Title | Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 57, Page 1914-1931, Year 2014 |
| Publish date | Aug 30, 2013 (structure data deposition date) |
 Authors | Talamas, F.X. / Abbot, S.C. / Anand, S. / Brameld, K.A. / Carter, D.S. / Chen, J. / Davis, D. / de Vicente, J. / Fung, A.D. / Gong, L. ...Talamas, F.X. / Abbot, S.C. / Anand, S. / Brameld, K.A. / Carter, D.S. / Chen, J. / Davis, D. / de Vicente, J. / Fung, A.D. / Gong, L. / Harris, S.F. / Inbar, P. / Labadie, S.S. / Lee, E.K. / Lemoine, R. / Le Pogam, S. / Leveque, V. / Li, J. / McIntosh, J. / Najera, I. / Park, J. / Railkar, A. / Rajyaguru, S. / Sangi, M. / Schoenfeld, R.C. / Staben, L.R. / Tan, Y. / Taygerly, J.P. / Villasenor, A.G. / Weller, P.E. |
 External links | J. Med. Chem. / PubMed:24195700 |
| Methods | X-ray diffraction |
| Resolution | 2.3 - 2.8 Å |
| Structure data |  PDB-4mia:  PDB-4mib: |
| Chemicals |  ChemComp-ZN:  ChemComp-28L:  ChemComp-HOH:  ChemComp-DMS:  ChemComp-28M: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / polymerase / TRANSFERASE-TRANSFERASE INHIBITOR complex / transferase / ns5b |
hepatitis c virus