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TitleSteric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
Journal, issue, pagesJ. Mol. Biol., Vol. 426, Page 1390-1406, Year 2014
Publish dateAug 29, 2013 (structure data deposition date)
AuthorsDe, S. / Chan, A.C. / Coyne, H.J. / Bhachech, N. / Hermsdorf, U. / Okon, M. / Murphy, M.E. / Graves, B.J. / McIntosh, L.P.
External linksJ. Mol. Biol. / PubMed:24333486
MethodsNMR (solution) / X-ray diffraction
Resolution2.199 Å
Structure data

PDB-2md5:
Structure of uninhibited ETV6 ETS domain
Method: SOLUTION NMR

PDB-4mhg:
Crystal structure of ETV6 bound to a specific DNA sequence
Method: X-RAY DIFFRACTION / Resolution: 2.199 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / Protein / Auto-inhibition / TRANSCRIPTION/DNA / ETS domain / Transcription Factor / TRANSCRIPTION-DNA complex

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