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| Title | Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network. |
|---|---|
| Journal, issue, pages | J. Biol. Chem., Vol. 289, Page 6799-6808, Year 2014 |
| Publish date | Aug 2, 2013 (structure data deposition date) |
Authors | Xu, S. / Hermanson, D.J. / Banerjee, S. / Ghebreselasie, K. / Clayton, G.M. / Garavito, R.M. / Marnett, L.J. |
External links | J. Biol. Chem. / PubMed:24425867 |
| Methods | X-ray diffraction |
| Resolution | 2.01 - 2.45 Å |
| Structure data | ![]() PDB-4m10: ![]() PDB-4m11: ![]() PDB-4o1z: |
| Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-HEM: ![]() ChemComp-ICD: ![]() ChemComp-BOG: ![]() ChemComp-HOH: ![]() ChemComp-MXM: |
| Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / NSAID / COX / dioxygenase / peroxidase / glycosylation / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / NSAIDs / Membrane |
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