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Title | Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities |
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Journal, issue, pages | J. Med. Chem., Vol. 45, Page 3905-3927, Year 2002 |
Publish date | Jul 31, 2013 (structure data deposition date) |
![]() | Kim, K.S. / Kimball, S.D. / Misra, R.N. / Rawlins, D.B. / Hunt, J.T. / Xiao, H.-Y. / Lu, S. / Qian, L. / Han, W.C. / Shan, W. ...Kim, K.S. / Kimball, S.D. / Misra, R.N. / Rawlins, D.B. / Hunt, J.T. / Xiao, H.-Y. / Lu, S. / Qian, L. / Han, W.C. / Shan, W. / Mitt, T. / Cai, Z.-W. / Poss, M.A. / Zhu, H. / Sack, J.S. / Tokarski, J.S. / Chang, C.Y. / Pavletich, N. / Kamath, A. / Humphreys, W.G. / Marathe, P. / Bursuker, I. / Kellar, K.A. / Roongta, U. / Batorsky, R. / Mulheron, J.G. / Bol, D. / Fairchild, C.R. / Lee, F.Y. / Webster, K.R. |
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Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | ![]() PDB-4lyn: |
Chemicals | ![]() ChemComp-1YG: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / KINASE / MITOSIS / CELL CYCLE / TRANSFERASE-TRANSFERASE INHIBITOR complex |