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TitleDiscovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development.
Journal, issue, pagesACS MED. CHEM. LETT., Vol. 5, Page 124-127, Year 2014
Publish dateJul 28, 2013 (structure data deposition date)
AuthorsZhang, Z. / Chu, X.J. / Liu, J.J. / Ding, Q. / Zhang, J. / Bartkovitz, D. / Jiang, N. / Karnachi, P. / So, S.S. / Tovar, C. ...Zhang, Z. / Chu, X.J. / Liu, J.J. / Ding, Q. / Zhang, J. / Bartkovitz, D. / Jiang, N. / Karnachi, P. / So, S.S. / Tovar, C. / Filipovic, Z.M. / Higgins, B. / Glenn, K. / Packman, K. / Vassilev, L. / Graves, B.
External linksACS MED. CHEM. LETT. / PubMed:24900784
MethodsX-ray diffraction
Resolution2.32 Å
Structure data

PDB-4lwv:
The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-20W:
(2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • xenopus laevis (African clawed frog)
KeywordsLigase/Ligase inhibitor / MDM2 / E3 Ubiquitin Ligase / p53 / Nucleus / Ligase-Ligase inhibitor complex

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