| タイトル | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. |
|---|
| ジャーナル・号・ページ | Eur. J. Med. Chem., Vol. 87, Page 765-781, Year 2014 |
|---|
| 掲載日 | 2013年7月27日 (構造データの登録日) |
|---|
 著者 | Chen, D. / Shen, A. / Li, J. / Shi, F. / Chen, W. / Ren, J. / Liu, H. / Xu, Y. / Wang, X. / Yang, X. ...Chen, D. / Shen, A. / Li, J. / Shi, F. / Chen, W. / Ren, J. / Liu, H. / Xu, Y. / Wang, X. / Yang, X. / Sun, Y. / Yang, M. / He, J. / Wang, Y. / Zhang, L. / Huang, M. / Geng, M. / Xiong, B. / Shen, J. |
|---|
 リンク | Eur. J. Med. Chem. / PubMed:25313505 |
|---|
| 手法 | X線回折 |
|---|
| 解像度 | 1.5 - 1.75 Å |
|---|
| 構造データ | PDB-4lwe:
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2
手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4lwf:
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3
手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4lwg:
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4
手法: X-RAY DIFFRACTION / 解像度: 1.599 Å PDB-4lwh:
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5
手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4lwi:
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6
手法: X-RAY DIFFRACTION / 解像度: 1.7 Å |
|---|
| 化合物 | ChemComp-FJ2:
N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide
ChemComp-FJ3:
4-(5-amino-1,2-oxazol-3-yl)-6-(propan-2-yl)benzene-1,3-diol
ChemComp-FJ4:
1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
ChemComp-FJ5:
N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazol-5-yl}cyclopropanecarboxamide
ChemComp-FJ6:
N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide
|
|---|
| 由来 |  homo sapiens (ヒト)
|
|---|
 キーワード | CHAPERONE / Rossmann Fold / ATP Binding / molecularchaperone |
|---|
ムービー
コントローラー
構造ビューア
万見文献について
