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Structure paper

TitleCrystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Journal, issue, pagesProtein Sci., Vol. 23, Page 289-301, Year 2014
Publish dateJun 18, 2013 (structure data deposition date)
AuthorsMabanglo, M.F. / Hast, M.A. / Lubock, N.B. / Hellinga, H.W. / Beese, L.S.
External linksProtein Sci. / PubMed:24347326
MethodsX-ray diffraction
Resolution1.45 - 1.905 Å
Structure data

PDB-4l9p:
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-4lnb:
Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5
Method: X-RAY DIFFRACTION / Resolution: 1.752 Å

PDB-4lng:
Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Method: X-RAY DIFFRACTION / Resolution: 1.905 Å

PDB-4mbg:
Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZN:
Unknown entry

ChemComp-FII:
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID

ChemComp-HOH:
WATER

ChemComp-FPP:
FARNESYL DIPHOSPHATE

ChemComp-ED5:
tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(2-methylphenyl)sulfonyl]amino}methyl)piperidine-1-carboxylate

ChemComp-JAN:
6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE / inhibitor*YM

ChemComp-K:
Unknown entry

Source
  • aspergillus fumigatus (mold)
KeywordsTRANSFERASE / Ternary complex with isoprenoid and CAAX peptide substrate / CAAX farnesyltransferase / Isoprenoid and CAAX protein/peptide substrate / isoprenoid and CAAX-containing protein substrate / farnesylation / Farnesyltransferase / Prenylation / Isoprenoid and CAAX-containing protein and peptide substrates / farnesyldiphosphate / farnesyltransferase inhibitor

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