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-Structure paper
Title | Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. |
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Journal, issue, pages | Nature, Vol. 501, Page 232-236, Year 2013 |
Publish date | Jul 10, 2013 (structure data deposition date) |
Authors | Hatzivassiliou, G. / Haling, J.R. / Chen, H. / Song, K. / Price, S. / Heald, R. / Hewitt, J.F. / Zak, M. / Peck, A. / Orr, C. ...Hatzivassiliou, G. / Haling, J.R. / Chen, H. / Song, K. / Price, S. / Heald, R. / Hewitt, J.F. / Zak, M. / Peck, A. / Orr, C. / Merchant, M. / Hoeflich, K.P. / Chan, J. / Luoh, S.M. / Anderson, D.J. / Ludlam, M.J. / Wiesmann, C. / Ultsch, M. / Friedman, L.S. / Malek, S. / Belvin, M. |
External links | Nature / PubMed:23934108 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-4lmn: |
Chemicals | ChemComp-ANP: ChemComp-MG: ChemComp-EUI: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase / Phosphorylation / Braf / TRANSFERASE-TRANSFERASE INHIBITOR complex |