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TitleMechanism for activation of mutated epidermal growth factor receptors in lung cancer.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page E3595-E3604, Year 2013
Publish dateJul 9, 2013 (structure data deposition date)
AuthorsRed Brewer, M. / Yun, C.H. / Lai, D. / Lemmon, M.A. / Eck, M.J. / Pao, W.
External linksProc. Natl. Acad. Sci. USA / PubMed:24019492
MethodsX-ray diffraction
Resolution4 Å
Structure data

PDB-4ll0:
EGFR L858R/T790M in complex with PD168393
Method: X-RAY DIFFRACTION / Resolution: 4 Å

Chemicals

ChemComp-YUN:
N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / Kinase / PD168393 / 34-jab / transferase-transferase inhibitor complex

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