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Structure paper

TitleStructure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.
Journal, issue, pagesActa Crystallogr F Struct Biol Commun, Vol. 70, Page 299-304, Year 2014
Publish dateJun 27, 2013 (structure data deposition date)
AuthorsPark, J. / Lin, Y.S. / Tsantrizos, Y.S. / Berghuis, A.M.
External linksActa Crystallogr F Struct Biol Commun / PubMed:24598914
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4lfv:
Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-YS4:
[({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid)

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex

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