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Structure paper

TitleA G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.
Journal, issue, pagesNat. Chem. Biol., Vol. 10, Page 686-691, Year 2014
Publish dateMay 29, 2013 (structure data deposition date)
AuthorsHuang, H. / Suslov, N.B. / Li, N.S. / Shelke, S.A. / Evans, M.E. / Koldobskaya, Y. / Rice, P.A. / Piccirilli, J.A.
External linksNat. Chem. Biol. / PubMed:24952597
MethodsX-ray diffraction
Resolution2.186 - 3.12 Å
Structure data

PDB-4kzd:
Crystal structure of an RNA aptamer in complex with fluorophore and Fab
Method: X-RAY DIFFRACTION / Resolution: 2.186 Å

PDB-4kze:
Crystal structure of an RNA aptamer in complex with Fab
Method: X-RAY DIFFRACTION / Resolution: 2.404 Å

PDB-4q9q:
Crystal structure of an RNA aptamer bound to bromo-ligand analog in complex with Fab
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-4q9r:
Crystal structure of an RNA aptamer bound to trifluoroethyl-ligand analog in complex with Fab
Method: X-RAY DIFFRACTION / Resolution: 3.12 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-1TU:
4-(3,5-difluoro-4-hydroxybenzyl)-1,2-dimethyl-1H-imidazol-5-ol

ChemComp-HOH:
WATER

ChemComp-2ZZ:
(5Z)-5-(3-bromobenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one

ChemComp-2ZY:
(5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-3-(2,2,2-trifluoroethyl)-3,5-dihydro-4H-imidazol-4-one

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
Keywordsimmune system/rna / G-quadruplex / Fluorescence / Fluorophore binding / In vitro / immune system-rna complex / RNA / Fluorophore / RNA/immune system / RNA-immune system complex

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