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TitleStructure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 4652-4656, Year 2013
Publish dateMay 29, 2013 (structure data deposition date)
AuthorsPecchi, S. / Ni, Z.J. / Han, W. / Smith, A. / Lan, J. / Burger, M. / Merritt, H. / Wiesmann, M. / Chan, J. / Kaufman, S. ...Pecchi, S. / Ni, Z.J. / Han, W. / Smith, A. / Lan, J. / Burger, M. / Merritt, H. / Wiesmann, M. / Chan, J. / Kaufman, S. / Knapp, M.S. / Janssen, J. / Huh, K. / Voliva, C.F.
External linksBioorg. Med. Chem. Lett. / PubMed:23820386
MethodsX-ray diffraction
Resolution2.87 - 3.25 Å
Structure data

PDB-4kz0:
Structure of PI3K gamma with Imidazopyridine inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

PDB-4kzc:
Structure of PI3K gamma with Imidazopyridine inhibitors
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

Chemicals

ChemComp-1UJ:
methyl 2-(acetylamino)-1,3-benzothiazole-6-carboxylate

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-1UK:
N-{6-[6-amino-5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-a]pyridin-2-yl}acetamide

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Lipid Kinase / Transferase-Transferase Inhibitor complex

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