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Title | IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 8151-8162, Year 2013 |
Publish date | May 13, 2013 (structure data deposition date) |
Authors | Kunfermann, A. / Lienau, C. / Illarionov, B. / Held, J. / Grawert, T. / Behrendt, C.T. / Werner, P. / Hahn, S. / Eisenreich, W. / Riederer, U. ...Kunfermann, A. / Lienau, C. / Illarionov, B. / Held, J. / Grawert, T. / Behrendt, C.T. / Werner, P. / Hahn, S. / Eisenreich, W. / Riederer, U. / Mordmuller, B. / Bacher, A. / Fischer, M. / Groll, M. / Kurz, T. |
External links | J. Med. Chem. / PubMed:24032981 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-4kp7: |
Chemicals | ChemComp-MN3: ChemComp-NAP: ChemComp-1UQ: ChemComp-HOH: |
Source |
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Keywords | oxidoreductase/oxidoreductase INHIBITOR / DXP pathway / drug optimization / non-covalent inhibition / malaria / tuberculosis / Rossmann fold / Reductoisomerase / NADPH Binding / Apicoplast / oxidoreductase-oxidoreductase INHIBITOR complex |