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TitleNovel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 4381-4387, Year 2013
Publish dateMay 9, 2013 (structure data deposition date)
AuthorsSteinig, A.G. / Li, A.H. / Wang, J. / Chen, X. / Dong, H. / Ferraro, C. / Jin, M. / Kadalbajoo, M. / Kleinberg, A. / Stolz, K.M. ...Steinig, A.G. / Li, A.H. / Wang, J. / Chen, X. / Dong, H. / Ferraro, C. / Jin, M. / Kadalbajoo, M. / Kleinberg, A. / Stolz, K.M. / Tavares-Greco, P.A. / Wang, T. / Albertella, M.R. / Peng, Y. / Crew, L. / Kahler, J. / Kan, J. / Schulz, R. / Cooke, A. / Bittner, M. / Turton, R.W. / Franklin, M. / Gokhale, P. / Landfair, D. / Mantis, C. / Workman, J. / Wild, R. / Pachter, J. / Epstein, D. / Mulvihill, M.J.
External linksBioorg. Med. Chem. Lett. / PubMed:23773865
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4knb:
C-Met in complex with OSI ligand
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-1RU:
7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine

ChemComp-GBL:
GAMMA-BUTYROLACTONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / protein kinase

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