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TitleIdentification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 4875-4885, Year 2013
Publish dateApr 27, 2013 (structure data deposition date)
AuthorsDragovich, P.S. / Bair, K.W. / Baumeister, T. / Ho, Y.C. / Liederer, B.M. / Liu, X. / Liu, Y. / O'Brien, T. / Oeh, J. / Sampath, D. ...Dragovich, P.S. / Bair, K.W. / Baumeister, T. / Ho, Y.C. / Liederer, B.M. / Liu, X. / Liu, Y. / O'Brien, T. / Oeh, J. / Sampath, D. / Skelton, N. / Wang, L. / Wang, W. / Wu, H. / Xiao, Y. / Yuen, P.W. / Zak, M. / Zhang, L. / Zheng, X.
External linksBioorg. Med. Chem. Lett. / PubMed:23899614
MethodsX-ray diffraction
Resolution1.84 Å
Structure data

PDB-4kfp:
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

Chemicals

ChemComp-1R7:
N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide

ChemComp-PO4:
PHOSPHATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Transferase-Transferase Inhibitor complex

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