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TitleDimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 3367-3378, Year 2013
Publish dateMar 22, 2013 (structure data deposition date)
AuthorsDesvergne, A. / Genin, E. / Marechal, X. / Gallastegui, N. / Dufau, L. / Richy, N. / Groll, M. / Vidal, J. / Reboud-Ravaux, M.
External linksJ. Med. Chem. / PubMed:23540790
MethodsX-ray diffraction
Resolution2.8 - 3.1 Å
Structure data

PDB-4jsq:
Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:4e
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-4jsu:
Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:3a
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-4jt0:
Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:4a
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-0L1:
hexanedioic acid

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / UPS / proteasome / drug discovery / non-covalent reversible inhibition / bivalence / TMC-95A derivatives / Ntn hydrolase / non-lysosomal protein breakdown / HYDROLASE-HYDROLASE INHIBITOR complex

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