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TitleStructures of Pseudomonas Aeruginosa Beta-Keto-Acyl-(Acyl-Carrier-Protein) Synthase II (Fabf) and a C164Q Mutant Provide Templates for Antibacterial Drug Discovery and Identify a Buried Potassium Ion and a Ligand-Binding Site that is an Artefact of the Crystal Form
Journal, issue, pagesActa Crystallogr. ,Sect. F, Vol. 71, Page 1020-, Year 2015
Publish dateAug 22, 2012 (structure data deposition date)
AuthorsBaum, B. / Lecker, L.S.M. / Zoltner, M. / Jaenicke, E. / Schnell, R. / Hunter, W.N. / Brenk, R.
External linksActa Crystallogr. ,Sect. F / PubMed:26249693
MethodsX-ray diffraction
Resolution1.67 - 2.4 Å
Structure data

PDB-4b7v:
Structure of wild type Pseudomonas aeruginosa FabF (KASII)
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

PDB-4jb6:
Structure of Pseudomonas aeruginosa FabF mutant C164Q
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4jpf:
Structure of wild type Pseudomonas aeruginosa FabF (KASII) in Complex with ligand
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-1LR:
3-(benzoylamino)-2-hydroxybenzoic acid

ChemComp-MG:
Unknown entry

Source
  • pseudomonas aeruginosa (bacteria)
KeywordsTRANSFERASE / FATTY ACID BIOSYNTHESIS / FabF / KASII

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