Movie
Controller
Structure viewers
About Yorodumi Papers
+Search query
-Structure paper
| Title | Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 23, Page 3438-3442, Year 2013 |
| Publish date | Mar 5, 2013 (structure data deposition date) |
 Authors | Plummer, M.S. / Cornicelli, J. / Roark, H. / Skalitzky, D.J. / Stankovic, C.J. / Bove, S. / Pandit, J. / Goodman, A. / Hicks, J. / Shahripour, A. ...Plummer, M.S. / Cornicelli, J. / Roark, H. / Skalitzky, D.J. / Stankovic, C.J. / Bove, S. / Pandit, J. / Goodman, A. / Hicks, J. / Shahripour, A. / Beidler, D. / Lu, X.K. / Sanchez, B. / Whitehead, C. / Sarver, R. / Braden, T. / Gowan, R. / Shen, X.Q. / Welch, K. / Ogden, A. / Sadagopan, N. / Baum, H. / Miller, H. / Banotai, C. / Spessard, C. / Lightle, S. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:23582272 |
| Methods | X-ray diffraction |
| Resolution | 1.72 Å |
| Structure data |  PDB-4jib: |
| Chemicals |  ChemComp-ZN:  ChemComp-MG:  ChemComp-1L6:  ChemComp-HOH: |
| Source |
|
 Keywords | HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex |
homo sapiens (human)