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-Structure paper
Title | Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 74, Page 562-573, Year 2014 |
Publish date | Feb 20, 2013 (structure data deposition date) |
Authors | Vidadala, R.S. / Ojo, K.K. / Johnson, S.M. / Zhang, Z. / Leonard, S.E. / Mitra, A. / Choi, R. / Reid, M.C. / Keyloun, K.R. / Fox, A.M. ...Vidadala, R.S. / Ojo, K.K. / Johnson, S.M. / Zhang, Z. / Leonard, S.E. / Mitra, A. / Choi, R. / Reid, M.C. / Keyloun, K.R. / Fox, A.M. / Kennedy, M. / Silver-Brace, T. / Hume, J.C. / Kappe, S. / Verlinde, C.L. / Fan, E. / Merritt, E.A. / Van Voorhis, W.C. / Maly, D.J. |
External links | Eur. J. Med. Chem. / PubMed:24531197 |
Methods | X-ray diffraction |
Resolution | 1.95 Å |
Structure data | PDB-4jbv: |
Chemicals | ChemComp-V68: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / serine/threonine protein kinase / transferase / calcium-binding / ATP-binding / bumped kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |