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-Structure paper
| Title | Drugging MYCN through an Allosteric Transition in Aurora Kinase A. |
|---|---|
| Journal, issue, pages | Cancer Cell, Vol. 26, Page 414-427, Year 2014 |
| Publish date | Feb 14, 2013 (structure data deposition date) |
Authors | Gustafson, W.C. / Meyerowitz, J.G. / Nekritz, E.A. / Chen, J. / Benes, C. / Charron, E. / Simonds, E.F. / Seeger, R. / Matthay, K.K. / Hertz, N.T. ...Gustafson, W.C. / Meyerowitz, J.G. / Nekritz, E.A. / Chen, J. / Benes, C. / Charron, E. / Simonds, E.F. / Seeger, R. / Matthay, K.K. / Hertz, N.T. / Eilers, M. / Shokat, K.M. / Weiss, W.A. |
External links | Cancer Cell / PubMed:25175806 |
| Methods | X-ray diffraction |
| Resolution | 1.853 - 3.135 Å |
| Structure data | ![]() PDB-4j8m: ![]() PDB-4j8n: |
| Chemicals | ![]() ChemComp-CJ5: ![]() ChemComp-MG: ![]() ChemComp-PO4: ![]() ChemComp-DMS: ![]() ChemComp-EDO: ![]() ChemComp-HOH: |
| Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Aurora A / type II / kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE / kinase domain |
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homo sapiens (human)
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