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TitleStudies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 2283-2293, Year 2013
Publish dateJan 17, 2013 (structure data deposition date)
AuthorsJuknaite, L. / Sugamata, Y. / Tokiwa, K. / Ishikawa, Y. / Takamizawa, S. / Eng, A. / Sakai, R. / Pickering, D.S. / Frydenvang, K. / Swanson, G.T. ...Juknaite, L. / Sugamata, Y. / Tokiwa, K. / Ishikawa, Y. / Takamizawa, S. / Eng, A. / Sakai, R. / Pickering, D.S. / Frydenvang, K. / Swanson, G.T. / Kastrup, J.S. / Oikawa, M.
External linksJ. Med. Chem. / PubMed:23432124
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4isu:
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution.
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-IKM:
(4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
Keywordsmembrane protein/antagonist / AMPA receptor ligand-binding domain / GluR2-S1S2J / antagonist / membrane protein / membrane protein-antagonist complex

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