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Title2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.
Journal, issue, pagesAcs Chem. Biol., Vol. 8, Page 1187-1194, Year 2013
Publish dateDec 26, 2012 (structure data deposition date)
AuthorsDesimmie, B.A. / Demeulemeester, J. / Suchaud, V. / Taltynov, O. / Billamboz, M. / Lion, C. / Bailly, F. / Strelkov, S.V. / Debyser, Z. / Cotelle, P. / Christ, F.
External linksAcs Chem. Biol. / PubMed:23517458
MethodsX-ray diffraction
Resolution3.4 Å
Structure data

PDB-4ikf:
PFV intasome with inhibitor MB-76
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-NH4:
AMMONIUM ION

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HEZ:
HEXANE-1,6-DIOL

ChemComp-M76:
N-(4-fluorobenzyl)-2,3-dihydroxy-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Source
  • human spumaretrovirus
KeywordsVIRAL PROTEIN/DNA/INHIBITOR / Integrase zinc binding / core and DNA-binding domains / DNA integration / Inhibitor / Nucleus / VIRAL PROTEIN-DNA-INHIBITOR complex / endonuclease / nucleotidyltransferase / recombination / HHCC motif / DDE motif

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