Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	De novo fragment design: a medicinal chemistry approach to fragment-based lead generation.
Journal, issue, pages	J. Med. Chem., Vol. 56, Page 3115-3119, Year 2013
Publish date	Dec 18, 2012 (structure data deposition date)
Authors	Talamas, F.X. / Ao-Ieong, G. / Brameld, K.A. / Chin, E. / de Vicente, J. / Dunn, J.P. / Ghate, M. / Giannetti, A.M. / Harris, S.F. / Labadie, S.S. ...Talamas, F.X. / Ao-Ieong, G. / Brameld, K.A. / Chin, E. / de Vicente, J. / Dunn, J.P. / Ghate, M. / Giannetti, A.M. / Harris, S.F. / Labadie, S.S. / Leveque, V. / Li, J. / Lui, A.S. / McCaleb, K.L. / Najera, I. / Schoenfeld, R.C. / Wang, B. / Wong, A.
External links	J. Med. Chem. / PubMed:23509929
Methods	X-ray diffraction
Resolution	1.9 - 2.3 Å
Structure data	PDB-4ih5: Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds Method: X-RAY DIFFRACTION / Resolution: 1.9 Å PDB-4ih6: Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds Method: X-RAY DIFFRACTION / Resolution: 2.2 Å PDB-4ih7: Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds Method: X-RAY DIFFRACTION / Resolution: 2.3 Å
Chemicals	ChemComp-12R: 4-(2-phenylhydrazinyl)-1H-pyrazolo[3,4-d]pyrimidine ChemComp-HOH: WATER ChemComp-1EP: (5S)-3-(4-tert-butylbenzyl)-5-(propan-2-yl)imidazolidine-2,4-dione ChemComp-ZN: Unknown entry ChemComp-1ER: 3-(3-tert-butylphenyl)pyridin-2(1H)-one
Source	hepatitis c virus
Keywords	TRANSFERASE/TRANSFERASE INHIBITOR / Fragment based drug design / TRANSFERASE-TRANSFERASE INHIBITOR complex