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| Title | Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 56, Page 1614-1628, Year 2013 |
| Publish date | Dec 18, 2012 (structure data deposition date) |
Authors | Assaf, Z. / Larsen, A.P. / Venskutonyte, R. / Han, L. / Abrahamsen, B. / Nielsen, B. / Gajhede, M. / Kastrup, J.S. / Jensen, A.A. / Pickering, D.S. ...Assaf, Z. / Larsen, A.P. / Venskutonyte, R. / Han, L. / Abrahamsen, B. / Nielsen, B. / Gajhede, M. / Kastrup, J.S. / Jensen, A.A. / Pickering, D.S. / Frydenvang, K. / Gefflaut, T. / Bunch, L. |
External links | J. Med. Chem. / PubMed:23414088 |
| Methods | X-ray diffraction |
| Resolution | 1.24 - 2.65 Å |
| Structure data | ![]() PDB-4igr: ![]() PDB-4igt: |
| Chemicals | ![]() ChemComp-3ZA: ![]() ChemComp-K: ![]() ChemComp-CL: ![]() ChemComp-PO4: ![]() ChemComp-HOH: ![]() ChemComp-SO4: ![]() ChemComp-LI: ![]() ChemComp-GOL: |
| Source |
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Keywords | MEMBRANE PROTEIN / ionotropic glutamate receptor / kainate receptor / ligand-binding domain / agonist / AMPA receptor ligand-binding domain / GluR2-S1S2J |
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