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-Structure paper
Title | P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel non-peptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. |
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Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 57, Page 4920-4927, Year 2013 |
Publish date | Oct 16, 2012 (structure data deposition date) |
Authors | Yedidi, R.S. / Maeda, K. / Fyvie, W.S. / Steffey, M. / Davis, D.A. / Palmer, I. / Aoki, M. / Kaufman, J.D. / Stahl, S.J. / Garimella, H. ...Yedidi, R.S. / Maeda, K. / Fyvie, W.S. / Steffey, M. / Davis, D.A. / Palmer, I. / Aoki, M. / Kaufman, J.D. / Stahl, S.J. / Garimella, H. / Das, D. / Wingfield, P.T. / Ghosh, A.K. / Mitsuya, H. |
External links | Antimicrob. Agents Chemother. / PubMed:23877703 |
Methods | X-ray diffraction |
Resolution | 1.75 - 1.96 Å |
Structure data | PDB-4hla: PDB-4i8w: PDB-4i8z: |
Chemicals | ChemComp-017: ChemComp-HOH: ChemComp-G07: ChemComp-G08: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / darunavir / Protease / Hydrolase / Gag / Gag-pol / TMC114 / UIC-94017 / HYDROLASE-HYDROLASE INHIBITOR complex / HIV-1 protease / HIV-1 protease-inhibitor complex / GRL007 / protease inhibitor / non-peptidic protease inhibitor / GRL008 / non-peptidic inhibitor |