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Structure paper

TitleStructural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
Journal, issue, pagesFebs Lett., Vol. 587, Page 2325-2331, Year 2013
Publish dateDec 3, 2012 (structure data deposition date)
AuthorsZanotti, G. / Cendron, L. / Folli, C. / Florio, P. / Imbimbo, B.P. / Berni, R.
External linksFebs Lett. / PubMed:23792159
MethodsX-ray diffraction
Resolution1.67 - 1.69 Å
Structure data

PDB-4i85:
Crystal structure of transthyretin in complex with CHF5074 at neutral pH
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

PDB-4i87:
Crystal structure of TTR variant I84S in complex with CHF5074 at acidic pH
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-4i89:
Crystal structure of transthyretin in complex with diflunisal at acidic pH
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

ChemComp-H50:
1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid

ChemComp-HOH:
WATER

ChemComp-1FL:
5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID / antiinflammatory*YM

Source
  • homo sapiens (human)
Keywordstransport protein/inhibitor / amyloidosis / fibrillogenesis / amyloid fibrils / T3 or T4 hormone binding / Plasma / transport protein-inhibitor complex / Transthyretin / fibrillogenesis inhibitors / protein misfolding / T3 or T4 hormone / fibrillogenesis inhibitor / transthyretin stabilizers / T4 or T3 hormone

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