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TitleStructure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction.
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 1113-1123, Year 2013
Publish dateDec 1, 2012 (structure data deposition date)
AuthorsZhou, H. / Liu, L. / Huang, J. / Bernard, D. / Karatas, H. / Navarro, A. / Lei, M. / Wang, S.
External linksJ. Med. Chem. / PubMed:23244744
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-4i80:
Crystal structure of human menin in complex with a high-affinity macrocyclic peptidomimetics
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Source
  • homo sapiens (human)
  • synthetic (others)
KeywordsTRANSCRIPTION/INHIBITOR / menin / MEN1 / MLL / macrocyclic peptidomimetic / TRANSCRIPTION / TRANSCRIPTION-INHIBITOR complex

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