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TitleNovel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 3592-3598, Year 2013
Publish dateNov 28, 2012 (structure data deposition date)
AuthorsHurley, C.A. / Blair, W.S. / Bull, R.J. / Chang, C. / Crackett, P.H. / Deshmukh, G. / Dyke, H.J. / Fong, R. / Ghilardi, N. / Gibbons, P. ...Hurley, C.A. / Blair, W.S. / Bull, R.J. / Chang, C. / Crackett, P.H. / Deshmukh, G. / Dyke, H.J. / Fong, R. / Ghilardi, N. / Gibbons, P. / Hewitt, P.R. / Johnson, A. / Johnson, T. / Kenny, J.R. / Kohli, P.B. / Kulagowski, J.J. / Liimatta, M. / Lupardus, P.J. / Maxey, R.J. / Mendonca, R. / Narukulla, R. / Pulk, R. / Ubhayakar, S. / van Abbema, A. / Ward, S.I. / Waszkowycz, B. / Zak, M.
External linksBioorg. Med. Chem. Lett. / PubMed:23642482
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-4i5c:
The Jak1 kinase domain in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-C5I:
3-oxo-3-[(3R)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6H)-yl)piperidin-1-yl]propanenitrile

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase

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