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Structure paper

TitleHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 20, Page 90-98, Year 2013
Publish dateNov 18, 2012 (structure data deposition date)
AuthorsGuce, A.I. / Mortimer, S.E. / Yoon, T. / Painter, C.A. / Jiang, W. / Mellins, E.D. / Stern, L.J.
External linksNat. Struct. Mol. Biol. / PubMed:23222639
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-4i0p:
HLA-DO in complex with HLA-DM
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HLA-DM / HLA-DO / HLA-DR / peptide loading / inhibitor / enzyme HLA-DM

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