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-Structure paper
Title | Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 23, Page 2590-2594, Year 2013 |
Publish date | Nov 13, 2012 (structure data deposition date) |
Authors | Huang, X. / Cheng, C.C. / Fischmann, T.O. / Duca, J.S. / Richards, M. / Tadikonda, P.K. / Reddy, P.A. / Zhao, L. / Arshad Siddiqui, M. / Parry, D. ...Huang, X. / Cheng, C.C. / Fischmann, T.O. / Duca, J.S. / Richards, M. / Tadikonda, P.K. / Reddy, P.A. / Zhao, L. / Arshad Siddiqui, M. / Parry, D. / Davis, N. / Seghezzi, W. / Wiswell, D. / Shipps, G.W. |
External links | Bioorg. Med. Chem. Lett. / PubMed:23535330 |
Methods | X-ray diffraction |
Resolution | 1.399 - 1.7 Å |
Structure data | PDB-4hyh: PDB-4hyi: |
Chemicals | ChemComp-1AM: ChemComp-HOH: ChemComp-GOL: ChemComp-1AO: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / SERINE/THREONINE-PROTEIN KINASE CHK1 INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |