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Title | Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 2643-2656, Year 2014 |
Publish date | Oct 22, 2012 (structure data deposition date) |
Authors | G-Dayanandan, N. / Paulsen, J.L. / Viswanathan, K. / Keshipeddy, S. / Lombardo, M.N. / Zhou, W. / Lamb, K.M. / Sochia, A.E. / Alverson, J.B. / Priestley, N.D. ...G-Dayanandan, N. / Paulsen, J.L. / Viswanathan, K. / Keshipeddy, S. / Lombardo, M.N. / Zhou, W. / Lamb, K.M. / Sochia, A.E. / Alverson, J.B. / Priestley, N.D. / Wright, D.L. / Anderson, A.C. |
External links | J. Med. Chem. / PubMed:24568657 |
Methods | X-ray diffraction |
Resolution | 1.76 - 2 Å |
Structure data | PDB-4hoe: PDB-4hof: PDB-4hog: |
Chemicals | ChemComp-NDP: ChemComp-18G: ChemComp-GLY: ChemComp-GOL: ChemComp-HOH: ChemComp-18H: ChemComp-CL: |
Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Antifungal Agents / Candida albicans / Drug Design / Enzyme Inhibitors / Fungal Proteins / Structure-Activity Relationship / Tetrahydrofolate Dehydrogenase / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / Candida glabrata |