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-Structure paper
Title | Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 7371-7375, Year 2012 |
Publish date | Oct 4, 2012 (structure data deposition date) |
Authors | Rzasa, R.M. / Hu, E. / Rumfelt, S. / Chen, N. / Andrews, K.L. / Chmait, S. / Falsey, J.R. / Zhong, W. / Jones, A.D. / Porter, A. ...Rzasa, R.M. / Hu, E. / Rumfelt, S. / Chen, N. / Andrews, K.L. / Chmait, S. / Falsey, J.R. / Zhong, W. / Jones, A.D. / Porter, A. / Louie, S.W. / Zhao, X. / Treanor, J.J. / Allen, J.R. |
External links | Bioorg. Med. Chem. Lett. / PubMed:23149228 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-4heu: PDB-4hf4: |
Chemicals | ChemComp-ZN: ChemComp-SO4: ChemComp-15J: ChemComp-HOH: ChemComp-GOL: ChemComp-15H: |
Source |
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Keywords | hydrolase/hydrolase inhibitor / PDE10A / inhibitors / phosphodiesterase 10A / biaryl ethers / hydrolase-hydrolase inhibitor complex |