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-Structure paper
Title | Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 2556-2567, Year 2013 |
Publish date | Sep 19, 2012 (structure data deposition date) |
Authors | Andriani, G. / Amata, E. / Beatty, J. / Clements, Z. / Coffey, B.J. / Courtemanche, G. / Devine, W. / Erath, J. / Juda, C.E. / Wawrzak, Z. ...Andriani, G. / Amata, E. / Beatty, J. / Clements, Z. / Coffey, B.J. / Courtemanche, G. / Devine, W. / Erath, J. / Juda, C.E. / Wawrzak, Z. / Wood, J.T. / Lepesheva, G.I. / Rodriguez, A. / Pollastri, M.P. |
External links | J. Med. Chem. / PubMed:23448316 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-4h6o: |
Chemicals | ChemComp-HEM: ChemComp-NEE: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / sterol 14-alpha demethylase (CYP51) / cytochrome P450 / heme / oxidoreductase / monooxygenase / sterol biosynthesis / eukaryotic membranes / cytochrome P450 fold / endoplasmic reticulum membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |