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-Structure paper
Title | Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 7523-7529, Year 2012 |
Publish date | Sep 10, 2012 (structure data deposition date) |
Authors | Bhattacharya, S.K. / Aspnes, G.E. / Bagley, S.W. / Boehm, M. / Brosius, A.D. / Buckbinder, L. / Chang, J.S. / Dibrino, J. / Eng, H. / Frederick, K.S. ...Bhattacharya, S.K. / Aspnes, G.E. / Bagley, S.W. / Boehm, M. / Brosius, A.D. / Buckbinder, L. / Chang, J.S. / Dibrino, J. / Eng, H. / Frederick, K.S. / Griffith, D.A. / Griffor, M.C. / Guimaraes, C.R. / Guzman-Perez, A. / Han, S. / Kalgutkar, A.S. / Klug-McLeod, J. / Garcia-Irizarry, C. / Li, J. / Lippa, B. / Price, D.A. / Southers, J.A. / Walker, D.P. / Wei, L. / Xiao, J. / Zawistoski, M.P. / Zhao, X. |
External links | Bioorg. Med. Chem. Lett. / PubMed:23153798 |
Methods | X-ray diffraction |
Resolution | 1.99 - 2 Å |
Structure data | PDB-4h1j: PDB-4h1m: |
Chemicals | ChemComp-0YH: ChemComp-HOH: ChemComp-0YJ: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |