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Structure paper

TitleMechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 19, Page 1363-1371, Year 2012
Publish dateSep 5, 2012 (structure data deposition date)
AuthorsSchellenberg, M.J. / Appel, C.D. / Adhikari, S. / Robertson, P.D. / Ramsden, D.A. / Williams, R.S.
External linksNat. Struct. Mol. Biol. / PubMed:23104055
MethodsX-ray diffraction
Resolution1.5 - 2.556 Å
Structure data

PDB-4gyz:
Mus Musculus Tdp2 Bound to dAMP and Mg2+
Method: X-RAY DIFFRACTION / Resolution: 2.556 Å

PDB-4gz0:
Mus Musculus Tdp2-DNA Substrate Analog (5'-6-aminohexanol) Complex
Method: X-RAY DIFFRACTION / Resolution: 2.113 Å

PDB-4gz1:
Mus Musculus Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex at 1.5 Angstroms resolution
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4gz2:
Mus Musculus Tdp2 excluded ssDNA complex
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-D5M:
2'-DEOXYADENOSINE-5'-MONOPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-6AH:
6-aminohexan-1-ol

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-FMT:
FORMIC ACID

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / protein-DNA complex / DNA repair / 5'-DNA end processing / endonuclease/exonuclease/phosphatase domain / EEP domain / 5'-DNA end recognition / HYDROLASE/dna / EEP / 5'-end recognition / nuclear / HYDROLASE-dna complex

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