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TitlePotent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 1276-1290, Year 2013
Publish dateAug 31, 2012 (structure data deposition date)
AuthorsSalvador, L.A. / Taori, K. / Biggs, J.S. / Jakoncic, J. / Ostrov, D.A. / Paul, V.J. / Luesch, H.
External linksJ. Med. Chem. / PubMed:23350733
MethodsX-ray diffraction
Resolution1.55 Å
Structure data

PDB-4gvu:
Lyngbyastatin 7-Porcine Pancreatic Elastase Co-crystal Structure
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
  • lyngbya (bacteria)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / Cyanobacteria / Elastase / Lyngbyastatin 7 / HYDROLASE-HYDROLASE INHIBITOR complex

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