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-Structure paper
Title | Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 2059-2073, Year 2013 |
Publish date | Aug 30, 2012 (structure data deposition date) |
Authors | Addie, M. / Ballard, P. / Buttar, D. / Crafter, C. / Currie, G. / Davies, B.R. / Debreczeni, J. / Dry, H. / Dudley, P. / Greenwood, R. ...Addie, M. / Ballard, P. / Buttar, D. / Crafter, C. / Currie, G. / Davies, B.R. / Debreczeni, J. / Dry, H. / Dudley, P. / Greenwood, R. / Johnson, P.D. / Kettle, J.G. / Lane, C. / Lamont, G. / Leach, A. / Luke, R.W. / Morris, J. / Ogilvie, D. / Page, K. / Pass, M. / Pearson, S. / Ruston, L. |
External links | J. Med. Chem. / PubMed:23394218 |
Methods | X-ray diffraction |
Resolution | 1.49 Å |
Structure data | PDB-4gv1: |
Chemicals | ChemComp-0XZ: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / protein kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |