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Structure paper

TitleLSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Journal, issue, pagesMol. Cell, Vol. 49, Page 558-570, Year 2013
Publish dateAug 29, 2012 (structure data deposition date)
AuthorsFang, R. / Chen, F. / Dong, Z. / Hu, D. / Barbera, A.J. / Clark, E.A. / Fang, J. / Yang, Y. / Mei, P. / Rutenberg, M. ...Fang, R. / Chen, F. / Dong, Z. / Hu, D. / Barbera, A.J. / Clark, E.A. / Fang, J. / Yang, Y. / Mei, P. / Rutenberg, M. / Li, Z. / Zhang, Y. / Xu, Y. / Yang, H. / Wang, P. / Simon, M.D. / Zhou, Q. / Li, J. / Marynick, M.P. / Li, X. / Lu, H. / Kaiser, U.B. / Kingston, R.E. / Shi, Y.G.
External linksMol. Cell / PubMed:23260659
MethodsX-ray diffraction
Resolution1.998 - 2.939 Å
Structure data

PDB-4gu1:
Crystal structure of LSD2
Method: X-RAY DIFFRACTION / Resolution: 2.939 Å

PDB-4gur:
Crystal structure of LSD2-NPAC with H3 in space group P21
Method: X-RAY DIFFRACTION / Resolution: 2.506 Å

PDB-4gus:
Crystal structure of LSD2-NPAC with H3 in space group P3221
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

PDB-4gut:
Crystal structure of LSD2-NPAC
Method: X-RAY DIFFRACTION / Resolution: 1.998 Å

PDB-4guu:
Crystal structure of LSD2-NPAC with tranylcypromine
Method: X-RAY DIFFRACTION / Resolution: 2.302 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-IOD:
IODIDE ION

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-FA9:
[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(3R,3aS,7aR)-10,11-dimethyl-1,4,6-trioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / histone demethylase

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