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TitleStructural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 44581-44591, Year 2012
Publish dateAug 23, 2012 (structure data deposition date)
AuthorsReynald, R.L. / Sansen, S. / Stout, C.D. / Johnson, E.F.
External linksJ. Biol. Chem. / PubMed:23118231
MethodsX-ray diffraction
Resolution2.87 Å
Structure data

PDB-4gqs:
Structure of Human Microsomal Cytochrome P450 (CYP) 2C19
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-0XV:
(4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / monooxygenase / drug metabolizing enzyme / heme protein

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