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-Structure paper
Title | Lead identification of novel and selective TYK2 inhibitors. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 67, Page 175-187, Year 2013 |
Publish date | Aug 3, 2012 (structure data deposition date) |
![]() | Liang, J. / Tsui, V. / Van Abbema, A. / Bao, L. / Barrett, K. / Beresini, M. / Berezhkovskiy, L. / Blair, W.S. / Chang, C. / Driscoll, J. ...Liang, J. / Tsui, V. / Van Abbema, A. / Bao, L. / Barrett, K. / Beresini, M. / Berezhkovskiy, L. / Blair, W.S. / Chang, C. / Driscoll, J. / Eigenbrot, C. / Ghilardi, N. / Gibbons, P. / Halladay, J. / Johnson, A. / Kohli, P.B. / Lai, Y. / Liimatta, M. / Mantik, P. / Menghrajani, K. / Murray, J. / Sambrone, A. / Xiao, Y. / Shia, S. / Shin, Y. / Smith, J. / Sohn, S. / Stanley, M. / Ultsch, M. / Zhang, B. / Wu, L.C. / Magnuson, S. |
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Methods | X-ray diffraction |
Resolution | 2 - 2.403 Å |
Structure data | ![]() PDB-4gfm: ![]() PDB-4gfo: ![]() PDB-4gih: ![]() PDB-4gmy: ![]() PDB-4gvj: |
Chemicals | ![]() ChemComp-0X2: ![]() ChemComp-HOH: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-GOL: ![]() ChemComp-0X5: ![]() ChemComp-ADP: ![]() ChemComp-MG: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / o-phosphotyrosine / TRANSFERASE-TRANSFERASE INHIBITOR complex / protein kinase / phosphotransfer catalyst / Tyrosine Kinase / Kinase / ATP Binding / Inhibitor / JAK2 / JH1 kinase domain / phosphotransferase / phosphorylation / HYDROLASE |